Erratum: Triggers for genomic rearrangements: insights into genomic, cellular and environmental influences

Genomic insights into positive selection.

The traditional way of identifying targets of adaptive evolution has been to study a few loci that one hypothesizes a priori to have been under selection. This approach is complicated because of the confounding effects that population demographic history and selection have on patterns of DNA sequence variation. In principle, multilocus analyses can facilitate robust inferences of selection at i...

Genomic Rearrangements and Evolution

Genomic insights into head and neck cancer

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and is frequently impervious to curative treatment efforts. Similar to other cancers associated with prolonged exposure to carcinogens, HNSCCs often have a high burden of mutations, contributing to substantial inter- and intra-tumor heterogeneity. The heterogeneity of this malignancy is further increased by ...

Mechanisms for human genomic rearrangements

Genomic rearrangements describe gross DNA changes of the size ranging from a couple of hundred base pairs, the size of an average exon, to megabases (Mb). When greater than 3 to 5 Mb, such changes are usually visible microscopically by chromosome studies. Human diseases that result from genomic rearrangements have been called genomic disorders. Three major mechanisms have been proposed for geno...

Genomic insights into temperature-dependent transcriptional

Stephen M. J. Pollo, Abigail A. Adebusuyi, Timothy J. Straub, Julia M. Foght, Olga 4 Zhaxybayeva and Camilla L. Nesbø 5 Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada 6 Department of Biological Sciences, Dartmouth College, Hanover, NH, USA 7 Department of Computer Science, Dartmouth College, Hanover, NH, USA 8 Centre for Ecological and Evolutionary Synthesis...